Is IUI Treatment Painful
Jun 2025 None
IVF

Is IUI Treatment Painful? What to Expect During & After

Infertility represents a significant obstacle in achieving the desire for parenthood. However, in modern medicine, there are multiple ways to solve this issue, one of which includes Intrauterine Insemination or IUI for short. In this process, a washed sperm is directly placed inside of your uterus during ovulation using a thin tube known as a catheter. However, this begs the question - since the process of IUI is placing the sperm directly inside the uterus, is IUI treatment painful? Overall, the IUI procedure is typically not painful. However, there can be some level of discomfort after this procedure. 

In this blog, we shall go a bit more into detail regarding the pain - or lack thereof, in the IUI procedure and provide you with a few additional information. This additional information includes the likes of tips to minimize discomfort after IUI procedure and who should avoid this treatment. 

What Is Intrauterine Insemination (IUI)?

IUI Treatment Painful

Before we answer the question of is IUI treatment is painful, let's first understand what it is. In simple definition, Intrauterine Insemination or IUI for short, is a form of artificial insemination where the sperm is directly placed into the uterus of the woman. In this process, the doctors collect the semen sample and seperate the sperm from other fluids. Subsequently, they employ a syringe to directly inject the sperm into the uterus through a slender tube known as a catheter.

It is a relatively less invasive procedure when compared to other forms of assisted reproductive technology (ART), such as IVF, and has a decent success rate. That said, you do have to note that the specific success rate depends on several factors, such as age, infertility diagnosis, medications, and other forms of underlying fertility issues. 

Who Is Eligible To Undergo The IUI Procedure?

IUI is undoubtedly one of the best options for infertility treatment. Nonetheless, it is not suitable for everyone and may not be the best choice in all situations. If it is so, who is eligible to undergo the IUI procedure? Certain categories of individuals qualified for the IUI procedure encompass: 

  • Men who have a slightly low sperm count, motility, and/or morphology can benefit from IUI as the process involves washing and concentrating the sperm.
  • Couples who have not been able to conceive even after a year of constantly trying (6 months if the woman is older than 35) without any form of identified cause 
  • If the woman has cervical mucus that is hostile to sperm or if there is a cervical condition that hinders sperm passage, IUI can be used as it can bypass the cervix.
  • IUI is also used when a woman has mild endometriosis, especially when it is combined with fertility medications.
  • If a man has retrograde ejaculation or other forms of ejaculation problems, they can also benefit from sperm retrieval and the IUI process. 
  • IUI is frequently utilized when donor sperm is required, especially in cases where the male partner has azoospermia, genetic conditions, or significant sperm problems. It is also used by couples who are having difficulties such as erectile dysfunction, vaginismus, or performance anxiety can also benefit from IUI as it bypasses the need for sexual intercourse. 
  • In conditions where a woman produces antibodies against her partner's sperm, the IUI procedure can aid the reproduction process by washing away the antibodies and placing the sperm directly into the uterus.
  • Couples with irregular work schedules (e.g., frequent travel or military service) who struggle with timed intercourse may use IUI to better coordinate fertilization with ovulation. 
  • If the male partner has HIV or hepatitis, sperm washing followed by IUI can reduce the risk of transmission to the female partner or baby.
  • IUI is often paired with fertility drugs (like Clomiphene or Letrozole) to stimulate ovulation and increase the chances of conception, especially in women with hormonal imbalances like PCOS. 
  • When the female partner is still relatively young, and the male has borderline sperm parameters, IUI might be recommended before considering IVF.

These are just some of the categories of people who can benefit from using IUI as a fertility treatment. Even if you do not fall into any of these categories, your fertility expert can still recommend this treatment if they deem that it is one of the better options. 

Is The IUI Procedure Painful?

After covering some of the additional information regarding the process, let's now jump into the core question of this topic - is IUI treatment painful? The simple answer to this question is - no, IUI treatment is not painful. However, you shall feel discomfort around your abdomen area. Following is a general breakdown of what you can expect during the IUI process. 

What You Shall Feel During the Procedure  

The process of IUI is rather brief - only taking 5 to 10 minutes. That said, there are still a few things that you should expect during this process. Following is a summary of what you should expect and shall feel during this process step-by-step:

  • Positioning: You will recline on the examination table with your feet placed in stirrups, similar to the position during a gynecological exam. This can be somewhat uncomfortable.
  • Speculum Insertion: A speculum is gently inserted into your vagina to see what’s inside the cervix. During this insertion, you can feel slight pressure and a cool sensation. However, it is generally not painful.
  • Catheter Insertion: The catheter is inserted via the cervix into the uterus. Some of you will feel a mild cramping or pinching during this, especially if the cervix is a bit tight or if you are tense.
  • Sperm Introduction: Slowly, the washed and concentrated sperm sample is introduced into the uterus. This process is generally painless, although you can feel slight fullness or minor uterine cramping.

After the insemination, the experts may ask you to lie down for a bit to aid the sperm's movement towards the fallopian tubes.

Also Read:

Types of Fallopian Tube Blockage - Hardik IVF Center

Now, do note that the process is generally painless and you shall only feel mildly uncomfortable. This mild discomfort can occur generally due to the following:

  • Cervical Sensitivity: If it's hard to access your cervix or it's tightly closed, the movement of inserting the catheter might slightly be cumbersome, causing some cramping.
  • Uterine Reactivity: Your uterus might mildly contract in response to the catheter or the introduction of sperm.
  • Anxiety or stress: The stress and nervousness can cause your pelvic muscles to tighten, which makes it a bit more uncomfortable.

Is there pain after IUI?

Pain After IUI

While IUI procedure is not painful, it is not yet the final answer to if IUI treatment is painful. You should also know whether you experience pain after the IUI procedure. Luckily, here as well, you shouldn't feel pain after IUI, and at best, you can get some symptoms and discomfort. These can include:

  • Mild Cramping: It can be similar to menstrual cramps and will probably resolve after a few hours.
  • Spotting: You can also expect light bleeding from the cervix- caused by catheter insertion but it is generally harmless.
  • Bloating or abdominal pressure: This typically occurs if you have used ovulation stimulation medication.

Breast tenderness and mood changes: You can feel these effects as a side effect of hormonal medications used alongside IUI treatment.

Why You Might Feel Discomfort After the Procedure?

At this point, we have already clarified that you do not feel pain during or after the IUI process in general. However, we also mentioned that you can feel discomfort after this process. But why would you be uncomfortable following the procedure? Several key reasons for this are:

  • Ovulation pain: If you've been taking fertility medications to stimulate ovulation, your ovaries can become swollen and will be painful and are said to feel bloated or sore.
  • Uterine Sensitivity: Some women are more sensitive to the insertion of instruments into the uterus. If you are among them, the insertion can result in cramps, which can last a few hours.
  • Mild Cervical Irritation: Depending on the sensitivity of the cervix, the catheter can irritate the cervix to some extent, which can result in minor discomforting sensation.
  • Emotional Stress: The emotional stress of fertility treatment can cause your body to feel physically tense, and that can make you feel more uncomfortable.

When to call your doctor?

Although cramping, bloating, and spotting are completely normal after IUI, there are certain circumstances under which you need to call a professional. Some of the circumstances under which you should call your fertility clinic or physician are:

  • Severe or prolonged pelvic pain
  • Heavier bleeding
  • Fever or chills
  • Smelly or abnormal discharge from the vagina
  • Dizziness or fainting

These are symptoms signifying that you most likely have an infection or complications such as infection of the uterus or an allergic reaction. Should you face these issues, you should contact an expert immediately.

Tips To Minimize Discomfort After IUI

When it comes to IUI, mild discomfort is expected. However, you can take measures to reduce the discomforts that you face. Some of these measures include:

  • Rest for a few hours: Relax during the healing period to allow your body to recover.
  • Utilize a warm heating pad: Position it on your lower abdomen to alleviate bloating or cramping.
  • Hydrate with plenty of water: Stay moisturized to help relieve bloating and generally feel comfortable.
  • Dress comfortably: Loose-fitting, comfortable clothing reduces pressure on your abdomen.
  • Maintain stress levels under control: Explore methods for relaxation such as deep breathing exercises or meditation practices.
  • Eat light, balanced meals: Helps digestion and minimizes bloating.
  • Take over-the-counter pain medication when needed: Use pain medication meds for minor cramping if approved by your doctor.
  • Avoid sex for 24 to 48 hours:  Allows your body to recover and avoids discomfort.
  • Carefully need your doctor's instructions: Stick to all post-IUI care guidelines and call your clinic if needed.

Do note that the ones we mentioned here are just some of the tips that you can use to reduce the discomfort. Depending on the specifics of your circumstances, your experts can also suggest additional measures.

Who Should Avoid IUI Treatment? 

Avoid IUI Treatment

Now, although IUI is generally regarded as a valid treatment for infertility, you should note that not everybody is suitable for IUI treatment. There are some circumstances when you are not suitable and should avoid IUI treatment. Some of the circumstances when you would be someone who should avoid IUI treatment include:

  • If both of your fallopian tubes are blocked or severely scarred, as in this circumstance, sperm cannot reach the egg- making IUI ineffective.
  • IUI is also not recommended if you have moderate to severe endometriosis, as in advanced stages, endometriosis can affect egg quality and implantation.
  • This treatment is also not recommended if you are a male with an extremely low count or have severely poor sperm motility.
  • If you have a low ovarian reserve or are over 40 years old with poor egg quality, then the experts usually don't recommend IUI since it typically has a low success rate in older women.
  • If you have problems such as intrauterine adhesions or big fibroids, this treatment is not recommended, because they can impede sperm reaching the egg and implantation of the embryo.
  • If you or your partner are carriers of serious genetic disorders and are in need of pre-implantation genetic testing (PGT),  then you may be recommended In-vitro Fertilization (IVF) instead of IUI.
    IUI is also not recommended if you have 3-6 failed cycles.
  • Untreated thyroid dysfunction, uncontrolled diabetes, or other hormone-related conditions may negatively affect fertility and need to be managed first before going through this procedure.
  • If you've had repeated pregnancy losses, further testing is usually needed before attempting IUI, and IVF may be advised depending on the findings.
  • If you cannot produce viable eggs or carry a pregnancy, IUI isn’t applicable—other reproductive options like egg donation or surrogacy are needed.  

Hardik IVF: IUI Expertise You Can Trust 

So, is IUI treatment painful? It isn't - unless you encounter certain issues. But although as we have answered our main question, there is one question still to be answered: where do you go for the best IUI treatment in Nepal? One of the best places to do it is Hardik IVF and Fertility Center - where you can get the best IUI service in Nepal by expert hands through advanced technologies.

If you are in need of the best IUI treatment, then we at Hardik welcome you with open arms. And if you seek more information regarding various aspects of ART such as IVF, then feel free to check out some of our other blogs. Thanks for reading.

FAQ: Is IUI Treatment Painful? What to Expect During & After

1. Is IUI painful for virgin women?

There can be a bit of pain for virgins when the speculum is inserted due to an unopened vagina opening, but that too is soft and tolerable. If one tells the doctor about concerns in advance, one can make the process even more comfortable.

2. Which hurts more, IUI vs IVF?

IVF is also more invasive and potentially more painful due to hormone injections and egg retrieval. IUI is a simpler, quicker procedure and is often less painful in general.

3. Is IUI successful on the first attempt?

Yes, IUI may be successful on the first attempt, but success rates are based on age, fertility, health, and underlying conditions. Overall, the success rate for the first cycle varies between 10% and 20%.

4. Which is more painful, IUI or HSG?

HSG (hysterosalpingography) generally is reported as more uncomfortable than IUI due to the pain of dye injection and uterine cramping. IUI is less internal manipulation and is generally better tolerated.

5. How long does pain last after IUI?

Any cramping or discomfort following IUI will only endure a few hours to one day. Pain or increasing pain is best discussed with your physician.